Search results for "Bench to bedside"
showing 7 items of 7 documents
Palbociclib - from Bench to Bedside and Beyond.
2016
Endocrine therapy is the cornerstone in the treatment of hormone receptor-positive breast cancer. During the last decades, much has been learned about the subtle regulation of the cell cycle. In this tightly regulated network, cyclin-dependent kinases (CDKs) play a pivotal role. Especially CDK4/6 is the key regulator of the G1-S transition. Realizing its importance, specific inhibitors of CDK4/6 were developed. The drug most advanced in clinical development in this class is palbociclib (PD 0332991). This review highlights preclinical data and brings into focus early clinical trials that led to an accelerated approval by the US Food and Drug Administration (FDA) as first-line treatment in co…
Crossing frontiers in biomaterials and regenerative medicine
2008
From 28 May–1 June 2008, the 8th World Biomaterials Congress (WBC) was held in Amsterdam, The Netherlands. The meeting attracted 3052 participants from 82 countries, which has made this congress the largest meeting ever held in the field of biomaterials and regenerative medicine. More than 650 oral and 1500 poster contributions [1] were presented in 108 scientific sessions, divided into nine parallel sessions, including 48 dedicated symposia that had been proposed by international leaders in the field. The symposia each contained an invited keynote, providing expert opinions on current developments in biomaterials research. Historically, research in the field of biomaterials has focused on …
Molecular biomarkers in glaucoma
2013
The seventh annual ARVO/Pfizer Ophthalmic Research Institute conference was held Friday and Saturday, April 29 and 30, 2011, at the Fort Lauderdale Hyatt Regency Pier 66, Fort Lauderdale, Florida. The conference, funded by The ARVO Foundation for Eye Research through a grant from Pfizer Ophthalmics, provided an opportunity to gather experts from within and outside ophthalmology to determine the state of knowledge pertaining to molecular biomarkers associated with glaucoma, as well as the methods to identify and validate them to predict (a) those who would be susceptible to development of glaucoma; (b) markers that will enable prediction of glaucoma progression; and (c) markers that will pre…
Myocarditis: from bench to bedside. LT Cooper Jr (Ed.). Humana Press, Totowa, NJ, 2002. ISBN: 1 58829 112 X/03
2003
From Bench to Bedside—The Bad Berka Experience With First-in-Human Studies
2019
Precision oncology is being driven by rapid advances in novel diagnostics and therapeutic interventions, with treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations. Inherent in the theranostics paradigm is the assumption that diagnostic test results can precisely determine whether an individual is likely to benefit from a specific treatment. As part and integral in the current era of precision oncology, theranostics in the context of nuclear medicine aims to identify the appropriate molecular targets in neoplasms (diagnost…
Conclusions. Slowing aging and fighting age-related diseases, from bench to bedside?
2021
Abstract The multiple wide-ranging and diverse aspects of aging discussed in this volume are overviewed and integrated in order to move toward a better understanding of how to achieve successful aging. To this end, potential strategies capable of slowing aging and preventing age-related diseases are considered and actions proposed.
The Role of Erythropoietin in Aneurysmal Subarachnoid Haemorrhage: From Bench to Bedside
2014
Subarachnoid haemorrhage (SAH) caused by a ruptured aneurysm accounts for only 5 % of strokes, but occurs at a fairly young age and carries a poor prognosis. Delayed cerebral ischaemia (DCI) is an important cause of death and dependence after aneurysmal SAH. The current mainstay of preventing DCI is nimodipine and maintenance of normovolemia, but even with this strategy DCI occurs in a considerable proportion of patients.